Design and synthesis of new orally active nonpeptidic inhibitors of human neutrophil elastase

J Med Chem. 2000 Dec 28;43(26):4927-9. doi: 10.1021/jm0004087.
No abstract available

MeSH terms

  • Administration, Oral
  • Animals
  • Crystallography, X-Ray
  • Dogs
  • Drug Design
  • Enzyme Inhibitors / chemical synthesis*
  • Enzyme Inhibitors / chemistry
  • Enzyme Inhibitors / pharmacology
  • Haplorhini
  • Humans
  • Leukocyte Elastase / antagonists & inhibitors*
  • Oxadiazoles / chemical synthesis*
  • Oxadiazoles / chemistry
  • Oxadiazoles / pharmacology
  • Pyrimidinones / chemical synthesis*
  • Pyrimidinones / chemistry
  • Pyrimidinones / pharmacology
  • Rats
  • Structure-Activity Relationship

Substances

  • Enzyme Inhibitors
  • ONO 6818
  • Oxadiazoles
  • Pyrimidinones
  • Leukocyte Elastase